pI: 5.6669 |
Length (AA): 447 |
MW (Da): 49590 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
21 | 444 | 2gsa (A) | 7 | 432 | 11.00 | 0 | 1 | 0.9 | -0.11 |
43 | 445 | 1bw0 (A) | 6 | 413 | 44.00 | 0 | 1 | 1.59 | -1.77 |
5 | 447 | 2zy2 (A) | 24 | 527 | 18.00 | 0 | 1 | 1.04815 | 0.28 |
39 | 447 | 4ix8 (A) | 40 | 448 | 96.00 | 0 | 1 | 2.11589 | -1.51 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_128985)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G53970 | tyrosine aminotransferase |
Arabidopsis thaliana | AT4G28410 | tyrosine transaminase family protein |
Arabidopsis thaliana | AT2G20610 | S-alkyl-thiohydroximate lyase SUR1 |
Arabidopsis thaliana | AT2G24850 | tyrosine aminotransferase 3 |
Arabidopsis thaliana | AT5G36160 | tyrosine aminotransferase |
Arabidopsis thaliana | AT4G28420 | tyrosine transaminase family protein |
Brugia malayi | Bm1_31005 | tyrosine aminotransferase |
Caenorhabditis elegans | CELE_F42D1.2 | Protein TATN-1 |
Dictyostelium discoideum | DDB_G0287515 | tyrosine aminotransferase |
Drosophila melanogaster | Dmel_CG1461 | CG1461 gene product from transcript CG1461-RB |
Homo sapiens | 6898 | tyrosine aminotransferase |
Leishmania braziliensis | LbrM.35.2580 | tyrosine aminotransferase |
Leishmania donovani | LdBPK_362490.1 | tyrosine aminotransferase |
Leishmania infantum | LinJ.36.2490 | tyrosine aminotransferase |
Leishmania major | LmjF.36.2360 | tyrosine aminotransferase |
Leishmania mexicana | LmxM.36.2360 | tyrosine aminotransferase, putative |
Loa Loa (eye worm) | LOAG_03223 | tyrosine aminotransferase |
Mus musculus | ENSMUSG00000001670 | tyrosine aminotransferase |
Oryza sativa | 4329098 | Os02g0302400 |
Oryza sativa | 9267778 | Os02g0306401 |
Oryza sativa | 4340970 | Os06g0345200 |
Oryza sativa | 4350712 | Os11g0552000 |
Oryza sativa | 4329101 | Os02g0302700 |
Schmidtea mediterranea | mk4.013860.02 | |
Schmidtea mediterranea | mk4.010921.01 | Tyrosine aminotransferase |
Schmidtea mediterranea | mk4.004732.00 | Tyrosine aminotransferase |
Trypanosoma cruzi | TcCLB.510187.50 | tyrosine aminotransferase |
Trypanosoma cruzi | TcCLB.510795.10 | tyrosine aminotransferase |
Trypanosoma cruzi | TcCLB.510187.40 | tyrosine aminotransferase |
Trypanosoma cruzi | TcCLB.509041.10 | tyrosine aminotransferase, putative |
Trypanosoma cruzi | TcCLB.510187.20 | tyrosine aminotransferase, putative |
Trypanosoma cruzi | TcCLB.511461.20 | tyrosine aminotransferase |
Trypanosoma cruzi | TcCLB.510187.30 | tyrosine aminotransferase |
Trypanosoma cruzi | TcCLB.510187.70 | tyrosine aminotransferase, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Tyrosine aminotransferase | Compounds | References |